The Role Of Cues On Glycemic Control And Lipid Profile

Abstract Objective: Anxiety, depression, hormonal imbalance are major disorders of chronic stress that lead to the several pathophysiological complications if prolonged. There is little evidence reflecting that chronic unpredictable environmental stress may induce the predisposition of diabetes mellitus associated complications. However detailed investigation at molecular level is required to see the effect of chronic unpredictable environmental stress (CUES) at gene level. The present study investigates the role of CUES on glycemic control and lipid profile in female Swiss albino mice. Material Methods: Study was conduct on Swiss albino female mice that were randomly divided into two groups after acclimatization. The animals of the treatment group stress (n=5) were exposed to a series of different environmental mechanical chronic stress with different stressors for 16 weeks. Control animals (n=5) were not given chronic stress. Animals of both groups were weighed weekly along with weekly feed consumption, weekly fasting blood glucose monitoring. Blood from retro-orbital plexus was collected before sacrifice of animals ethically for analysis of HbA1c, serum HDL, VLDL, LDL, triglycerides. Results: Fasting blood glucose levels in the treatment group of the experiment were significantly higher compared to control mice. Total cholesterol, HDL, LDL, VLDL, triglycerides HbA1c were found to be significantly increased in the animals of the stressed group. Body weights of the